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Degradation of beta-catenin by the destruction complex. Regulation of activated PAK-2p34 by proteasome mediated degradation. Your access to the NCBI website at gov has been temporarily blocked due to a possible misuse/abuse situation involving your site.

The version number for both the entry and the canonical sequence are also displayed. This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by Uni Prot KB curators or not, in other words, if the entry belongs to the Swiss-Prot section of Uni Prot KB (reviewed) or to the computer-annotated Tr EMBL section (unreviewed). Any medical or genetic information present in this entry is provided for research, educational and informational purposes only.

The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). Additionally, this section gives relevant information on each alternative protein isoform. 10 20 30 40 50MGQSQSGGHG PGGGKKDDKD KKKKYEPPVP TRVGKKKKKT KGPDAASKLP 60 70 80 90 100LVTPHTQCRL KLLKLERIKD YLLMEEEFIR NQEQMKPLEE KQEEERSKVD 110 120 130 140 150DLRGTPMSVG TLEEIIDDNH AIVSTSVGSE HYVSILSFVD KDLLEPGCSV 160 170 180 190 200LLNHKVHAVI GVLMDDTDPL VTVMKVEKAP QETYADIGGL DNQIQEIKES 210 220 230 240 250VELPLTHPEY YEEMGIKPPK GVILYGPPGT GKTLLAKAVA NQTSATFLRV 260 270 280 290 300VGSELIQKYL GDGPKLVREL FRVAEEHAPS IVFIDEIDAI GTKRYDSNSG 310 320 330 340 350GEREIQRTML ELLNQLDGFD SRGDVKVIMA TNRIETLDPA LIRPGRIDRK 360 370 380 390 400IEFPLPDEKT KKRIFQIHTS RMTLADDVTL DDLIMAKDDL SGADIKAICT 410 420 430 440EAGLMALRER RMKVTNEDFK KSKENVLYKK QEGTPEGLYL The checksum is a form of redundancy check that is calculated from the sequence. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low. The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x x 1.

of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced. / Processing section describes covalent linkages of various types formed between two proteins (interchain cross-links) or between two parts of the same protein (intrachain cross-links), except the disulfide bonds that are annotated in the ‘Disulfide bond’ subsection. Component of the 19S proteasome regulatory particle complex. This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). However Uni Prot KB may contain entries with identical sequences in case of multiple genes (paralogs).

Upon integration into Uni Prot KB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’. This subsection of the ‘Entry information’ section shows the date of integration of the entry into Uni Prot KB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’).

These are stable identifiers and should be used to cite Uni Prot KB entries.

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